Riboswitches and Ribozymes

Ribozymes are catalytic RNAs that interact with a variety of small molecule substrates and cofactors, the intracellular abundance of which are sensed by riboswitches that modulate transcription, RNA stability, or translation. Here is the latest research.

January 20, 2022

Lipid membranes modulate the activity of RNA through sequence-dependent interactions.

Proceedings of the National Academy of Sciences of the United States of America
Tomasz Czerniak, James P Saenz
January 14, 2022

Application of RtcB ligase to monitor self-cleaving ribozyme activity by RNA-seq.

Biological Chemistry
V Janett OlzogChristina E Weinberg
January 13, 2022

An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch.

Nature Communications
Rajeev YadavNils G Walter
January 13, 2022

A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control.

Nature Communications
Griffin M SchroederJoseph E Wedekind
January 13, 2022

Dynamic RNA fitness landscapes of a group I ribozyme during changes to the experimental environment.

Molecular Biology and Evolution
Gianluca PeriEric J Hayden
January 12, 2022
Preprint
Open Access

A split ribozyme that links detection of a native RNA to orthogonal protein outputs

BioRxiv : the Preprint Server for Biology
L. GambillJames Chappell
January 12, 2022
Open Access

Exploring the Catalytic Mechanism of the RNA Cap Modification by nsp16-nsp10 Complex of SARS-CoV-2 through a QM/MM Approach.

International Journal of Molecular Sciences
José Rogério A SilvaCláudio Nahum Alves
January 12, 2022

Alternative polyadenylation by sequential activation of distal and proximal PolyA sites.

Nature Structural & Molecular Biology
Peng TangYu Zhou
January 8, 2022

Ribozyme Mutagenic Evolution: Mechanisms of Survival.

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
Carolina Diaz ArenasYohei Yokobayashi
January 4, 2022

The RNase P, LUCA, the ancestors of the life domains, the progenote, and the tree of life.

Bio Systems
Massimo Di Giulio
December 27, 2021

CRISPR/Cas9-mediated demethylation of FOXP3-TSDR toward Treg-characteristic programming of Jurkat T cells.

Cellular Immunology
Camilla WilkJan Kehrmann
December 27, 2021

Catalytic activities, molecular connections, and biological functions of plant RNA exosome complexes.

The Plant Cell
Heike Lange, Dominique Gagliardi
December 28, 2021

Lysine-Dependent Entropy Effects in the B. subtilis Lysine Riboswitch: Insights from Single-Molecule Thermodynamic Studies.

The Journal of Physical Chemistry. B
Andrea Marton Menendez, David J Nesbitt
December 25, 2021
Open Access

Genome Evolution from Random Ligation of RNAs of Autocatalytic Sets.

International Journal of Molecular Sciences
Felix Broecker
December 25, 2021
Open Access

Pan-Genomic Sequencing Reveals Actionable CDKN2A/2B Deletions and Kataegis in Anaplastic Thyroid Carcinoma.

Cancers
Adam StenmanC Christofer Juhlin

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